An advanced generation of adenoviral vectors selectively enhances gene transfer for ovarian cancer gene therapy approaches Gynecol Oncol 1999 74: 227 227 Genetic targeting of adenoviral vectors Mol Ther 2000 1: 391 391 Krasnykh V.N., Douglas J.T., van Beusechem V.W. Differential signaling by an Anti-p185HER2 antibody and heregulin Cancer Res 2000 60: 3522 3522
Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of Her-2 Cancer Res 2000 60: 2284 2284 Klapper L.N., Waterman H., Sela M., Yarden Y. Selection of tumor-specific internalizing human anitbodies from phage libraries J Mol Biol 2000 301: 1149 1149 Herceptin (trastuzamab) in advanced breast cancer Can Tr Rev 2000 26: 287 287 Pharmacokinetics and biodistribution of engineered single-chain antibody constructs of Mab CC49 in colon carcinoma xenografts J Nucl Med 1999 40: 1536 1536 Antibody therapy of acute myelogenous leukemia Cancer Biother Radiopharm 2000 15: 319 319 Recombinant antibodies: a novel approach to cancer diagnosis therapy Expert Opin Invest Drugs 2000 9: 1231 1231 This method will likely have applicability for a range of disorders amenable to targeted therapeutic approaches. In vivo gene transfer clearly represents a powerful means to realize effective scFv-based approaches. Thus, by virtue of engineering a secreted version of the anti-tumor anti-erbB-2 scFv, and in vivo expression via adenoviral vector, effective concentrations of scFv were achieved. In vivo gene transfer via the anti-erbB2 scFv encoding adenovirus also showed anti-tumor effects. Adenoviral vectors expressing the cDNA for the secretory scFv likewise could induce target cells to produce an anti-tumor anti-erbB2 scFv. The secreted scFv could bind to its target and specifically suppress cell growth of erbB2-positive cells in vitro. An anti-erbB2 scFv was engineered for secretion by eukaryotic cells.
To circumvent these limitations, we have developed an approach to express scFv in vivo. The practical utility of these agents have been limited, however, by difficulties related to production of recombinant scFv and the achievement of effective and sustained levels of scFv in situ. Single chain antibodies (scFv) represent powerful interventional agents for the achievement of targeted therapeutics. The Castaic Lake Dragon Boat Club accepts paddlers of all ages and sizes, from beginners to experts, and meets Sunday mornings at Castaic Lake’s lower lagoon, located at 32132 Castaic Lake Drive. Throughout the year the Castaic Lake Dragon Boat Club hosts events, including an Easter egg hunt, which became an annual occurrence after gaining popularity, allowing participants to search for “eggs” both on and off the water.Īdditionally, the club hosts an annual Dragon Boat Festival, which they hope to bring back next year. The Dragon Eyes dragon boat team practices on Castaic Lake Sunday morning. “I have a lot of friends here, and it’s super fun to bond with people and paddle together,” he added. Prakash trained hard to make the team, shaving almost a minute off his time through practice.įor Prakash, it’s the social aspect that drew him in, and he has since found his passion for the sport.
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“It keeps the tempo of the boat to let everyone know how to go,” Prakash said of drumming. Their hard work seemed to have paid off, as four members of the Castaic team ended up making the 30-person team out of more than 200-300 applicants nationally.Īmong those who made the national team is 14-year-old Varun Prakash, who, as the team’s drummer, also did time trials, which he said involved a lot of training, but was worth it. “It took a lot of hard work, a lot of dedication.” “We were here like every morning,” Pascua added. Pascua only started paddling in 2017, but his passion quickly grew, and soon, he found himself training at least two hours, sometimes four, every day. “It was really tough because we had no idea how to use the OCs when we first started - it’s a whole different animal,” head coach Rey Pascua said. national team, which worked out perfectly as they had to use the OC1s for their time trials. It was around that same time that some of the team’s members decided to take their paddling a step farther, choosing to train to join the U.S.
SCV Signal News Podcast with Aron Bender.
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